On a stormy night, Chucky's voodoo obsessed girlfriend Tiffany finally found the remains of the doll. After slitting a cop's throat, she goes back to her trailer and sews Chucky back together. She uses a book entitled "Voodoo 4 Dummies" and brings him back to life with a spell. However, soon after bringing him back Tiffany found out that the ring she had worn for 10 years had not been for a proposal. It was actually a ring that Chucky had stolen from a woman named Vivian Van Pelt.
Seeing that all Chucky was interested in was becoming human again, she became furious and locked him away in the playpen which she had bought for the child she wanted to have. After escaping, Chucky kills Tiffany by electrocuting her in her bathtub. He then brings her back as a women's bridal doll that Tiffany originally bought for him as a joke. Tiffany wanted out of the doll body right away. Chucky then tells her that the only way to turn human again was to use The Heart of Damballa, an amulet that Chucky was wearing on the night he became a doll. In order to get to Hackensack, New Jersey where his corpse was buried, Tiffany calls her neighbor Jesse (played by Nick Stabile) and says she'll pay him to get them there by the next day. Unaware of the fact that Tiffany and Chucky were alive, he takes advantage of this opportunity to escape with his girlfriend Jade from her overprotective uncle Warren. He accepts the offer and runs away with Jade as quick as possible.
On the way there, Tiffany and Chucky kill anyone who stalls their ride, but Jesse and Jade get blamed for all of it. They then decide to stop at a motel and rest. At the motel, they meet a pair of newlyweds named Diane and Russ, who are later sliced by falling shards of glass above them when Tiffany throws a wine bottle at a mirror on the ceiling. Chucky, awestruck at the creative murder, then proposed to Tiffany and they have sex. When the bodies of the newlyweds are discovered by the hotel maid, Jesse and Jade are even more wanted then ever, so their friend David comes to give them some advice. It is during this time that Jesse and Jade find out the dolls are alive, and there's no turning back now. After hijacking a recreational vehicle from another couple, Jesse and Jade are both forced to drive to Hackensack.
On the way, Tiffany and Chucky wind up getting into a fight (provoked by Jesse and Jade), and Jesse (who was driving) crashes the van and it explodes. That doesn't stop them, though. They wind up getting to Forrest Creek Cemetery, but right before Tiffany was about to transfer her soul into Jade, she and Chucky get into another fight. Tiffany winds up being killed, and when the cops show up, Chucky gets shot by Jade. Before her final breath, Tiffany gives birth to a bloody baby doll (Glen/Glenda